Regulation of Receptors and Digestive Activity Toward Synthesized
نویسندگان
چکیده
A receptor binding and digestive activity of human polymorphonuclear leukocytes (PMNs) toward formyl-methionyl-leucyI3H]phenylalanine (3H-FMLP) was examined with the following results: (1 ) Upand down-regulation and recovery of 3H-FMiP binding activity were demonstrated. (2) Both intact PMN and a lysate prepared from them cleaved the carboxyl terminal amino acid (phenylalanine) of 3H-FMiP. (3) The digestive activity decreased as the receptor binding was inhibited by n-ethylmaleimide and 4-chloromercuribenzoate. (4) iittle digestive activity was found in the supernatant from PMN stimulated by FMLP. (5) The released phenylalanine was found in the pellet and supernatant of PMNs. (6) Digestive activity with cathepsin
منابع مشابه
Regulation of receptors and digestive activity toward synthesized formyl-chemotactic peptide in human polymorphonuclear leukocytes.
A receptor binding and digestive activity of human polymorphonuclear leukocytes (PMNs) toward formyl-methionyl-leucyl-[3H]phenylalanine (3H-FMLP) was examined with the following results: Up- and down-regulation and recovery of 3H-FMLP binding activity were demonstrated. Both intact PMN and a lysate prepared from them cleaved the carboxyl terminal amino acid (phenylalanine) of 3H-FMLP. The diges...
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